TABLE II.
Example studies using polygenic risk scores (PRSs) for brain imaging genomics. A PRS summarizes the aggregate effect from an ensemble of SNPs related to a base phenotype. The effect of the PRS is examined on interesting imaging QTs.
| Ref | Notes |
|---|---|
| [58] | PRS: Power and predictive accuracy |
| [59] | PRS: Usefulness and applications in imaging genetics |
| [46] | Standard PRS workflow, image-based DPS |
| [61] | Standard PRS workflow, hippocampal volume |
| [62] | Standard PRS workflow, cortical thickness |
| [65] | PHS instead of PRS, amyloid and MR imaging QTs |
| [67] | PRSice: PRS software, http://prsice.info/ |