. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: Bioorg Med Chem. 2019 Nov 11;28(1):115193. doi: 10.1016/j.bmc.2019.115193

Table 3.

Human β-cell replication and R7T1 β-cell cytotoxicity of selected compounds.

Compound	Human Islets EC_min (nM)	R7T1 CC₅₀ (nM)	Index, R7T1CC₅₀/Human Islet EC_min (nM)
5 (OTS167)	5	20	4
16	10	160	16
27	31	226	7.3
29	68	1,018	15
30	500	1712	3.4
31	250	785	3.1
34	3.3	387	117
38	250	>10,000	>40
42	31	2,814	91
43	125	1,790	14
45	125	231	1.8
46	250	2,080	8.3
47	63	2,440	39
48	500	1,080	2.2
49	63	1,390	22
52	250	>10,000	>40
56	27	3864	143
59	22	328	15
60	>500	330	n/a
63	3.3	856	259