Table 1.

Associations between inflammation and focal atrophy among men diagnosed with prostate cancer between 1983 and 2010 in the Health Professionals Follow-up Study and the Physicians’ Health Study.

	All men, n(%)	Men according to inflammation and atrophy lesions, n (%)a
		Acute inflammation	SA	PAH	SACF	Partial atrophy
Acute inflammation
Yes	299 (29.8)		266 (89.0)	93 (31.1)	79 (26.4)	8 (2.7)
No	703 (70.2)		473 (67.3)	120 (17.1)	107 (15.2)	15 (2.1)
			P < 0.0001	P < 0.0001	P < 0.0001	P = 0.59
Chronic inflammation
Moderate/Severe	339 (33.3)	208 (61.7)	302 (89.4)	118 (34.9)	67 (19.8)	9 (2.7)
Mild	516 (50.6)	85 (16.7)	375 (73.8)	90 (17.8)	103 (20.3)	12 (2.4)
None	164 (16.1)	5 (3.3)	62 (40.3)	5 (3.3)	16 (10.4)	2 (1.3)
		P < 0.0001	P < 0.0001	P < 0.0001	P = 0.02	P = 0.71b
SA
Yes	740 (73.7)			187 (25.3)	176 (23.8)	21 (2.8)
No	264 (26.3)			27 (10.2)	10 (3.8)	2 (0.8)
				P < 0.0001	P < 0.0001	P = 0.06b
PAH
Yes	214 (21.3)				49 (22.9)	10 (4.7)
No	789 (78.7)				137 (17.4)	13 (1.7)
					P = 0.06	P = 0.008
SACF
Yes	186 (18.5)					5 (2.7)
No	818 (81.5)					18 (2.2)
						P = 0.69
Partial atrophy
Yes	23 (2.3)
No	980 (97.7)

Abbreviations: SA, simple atrophy; PAH, postatrophic hyperplasia; SACF, simple atrophy with cyst formation.

Note: Among 1035 men diagnosed with prostate cancer, acute inflammation was missing for 33 men; chronic inflammation was missing for 16 men; SA was missing for 31 men; PAH was missing for 32 men; SACF was missing for 31 men; partial atrophy was missing for 32 men.

^aRow percentage restricted to patients positive for features including chronic inflammation, acute inflammation, SA, PAH, SACF and partial atrophy.

^bP-values based on the Fisher’s exact test; all other p-values based on the chi-square test.