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. 2019 Dec 30;12:11555–11565. doi: 10.2147/OTT.S232100

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© 2019 Yu et al.

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Overexpression of HOXA5 inhibits cell proliferation, cell cycle, and migration, but promote apoptosis. (A) Both mRNA and protein levels were elevated by lentivirus mediated transfection of HOXA5 gene in U2OS cells. (B) MTT assay shows that overexpression of HOXA5 inhibits cell proliferation. (C) FCM assay and quantitative assay showed that overexpression of HOXA5 increased cell numbers of G1 phase. (D) Transwell assay and quantitative assay showed that overexpression of HOXA5 inhibited cell migration. (E) FCM assay and quantitative assay showed that overexpression of HOXA5 promotes cell apoptosis. (F) Overexpression of HOXA5 could rescue the effects induced by miR-26a mimic in migration of osteosarcoma cells and (G) quantitative analysis. Data are presented as mean±S.D. of three independent experiments. *P<0.05, **P<0.01. Scale bar 200μm.