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. 2020 Jan 3;11:69. doi: 10.1038/s41467-019-13803-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Heatmap showing each compound (perturbagen) in rows from the Connectivity Map that share gene targets predicted as OCG (salmon) or TSG (teal) in columns. A red square indicates the presence of a relationship between compound and target. b Heatmap showing each compound (perturbagen) in columns from the Connectivity Map that shares mechanisms of action (rows), sorted by descending number of compounds with shared mechanisms of action. c Heatmap showing the top 50 TSG and OCG (by Moonlight Gene Z-score) predicted in breast cancer as mediators of apoptosis and proliferation (columns) and expression profiles of 50 breast-cancer cell lines from the Genomics of Drug Sensitivity in Cancer (GDSC) database (rows).