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. 2020 Jan 3;11:15. doi: 10.1038/s41467-019-13831-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Our pEWAS (green lines) identified multiple proteins (blue octagons) and CpG sites (green circles) that are related to major anti-inflammatory pathways, and that could be directly connected via intermediate genes and proteins using IPA (yellow diamonds). NLRC5 and beta-2-microglobulin both regulate the major histocompatibility complex MHC class I genes through interaction with various interleukins and NFκB. NLRC5 methylation also associated with various metabolic inflammatory markers (orange triangles). Finally, the associated proteins were are also associated with various clinical phenotypes in KORA at multiple-testing corrected significance levels (purple rectangles). NLRC5 methylation is a hallmark of chronic inflammation and has been reported in association with several inflammation-related diseases (pink hexagons). Full annotations of these links are provided in Supplementary Note 4.