Table 2.
Replicated NLRC5 pQTMs.
| CpG | pQTM (this study) | PpQTM | BetapQTM | eQTM (BIOS) | PeQTM | BetaeQTM |
|---|---|---|---|---|---|---|
| cg07839457 (NLRC5) chr16:57,023,022 | CD48 (3292-75_1) chr1:160,648,536-160,681,641 | 1.10 × 10−21 | −0.306 | n.a. | n.a. | n.a. |
| cg08159663 (NLRC5) chr16: 57,022,486 | CD48 | 3.38 × 10−12 | −0.246 | ENSG00000140853 NLRC5 | 8.26 × 10−10 | 0.213 |
| cg07839457 (NLRC5) chr16:57,023,022 | B2M (3485-28_2) chr15:45,003,675-45,011,075 | 7.60 × 10−20 | −0.292 | n.a. | n.a. | n.a. |
| cg16411857 (NLRC5) chr16:57,023,191 | B2M | 1.94 × 10−15 | −0.256 | n.a. | n.a. | n.a. |
| cg00218406 (HCP5) chr6:31,431,407 | B2M | 3.97 × 10−13 | −0.234 | ENSG00000206337 HCP5 | 7.78 × 10−102 | 0.454 |
| cg08099136 (PSMB8) chr6:32,811,251 | B2M | 4.80 × 10−11 | −0.214 | ENSG00000204264 PSMB8 | 1.96 × 10−23 | 0.258 |
| cg07839457 (NLRC5) chr16:57,023,022 | CXCL10 (4141-79_1) chr4:76,942,273-76,944,650 | 8.06 × 10−19 | −0.283 | n.a. | n.a. | n.a. |
| cg07839457 (NLRC5) chr16:57,023,022 | FCGR3B (3311-27_1) chr1:161,592,986-161,601,753 | 1.02 × 10−18 | −0.307 | n.a. | n.a. | n.a. |
| cg08159663 (NLRC5) chr16:57,022,486 | FCGR3B | 1.44 × 10−14 | −0.290 | ENSG00000140853 NLRC5 | 8.26 × 10−10 | 0.213 |
| cg16411857 (NLRC5) chr16:57,023,191 | FCGR3B | 3.79 × 10−13 | −0.260 | n.a. | n.a. | n.a. |
| cg07839457 (NLRC5) chr16:57,023,022 | LAG3 (5099-14_3) chr12:6,881,678-6,887,621 | 1.29 × 10−17 | −0.274 | n.a. | n.a. | n.a. |
| cg08159663 (NLRC5) chr16:57,022,486 | LAG3 | 9.22 × 10−13 | −0.246 | ENSG00000140853 NLRC5 | 8.26 × 10−10 | 0.213 |
| cg07839457 (NLRC5) chr16:57,023,022 | CD163 (5028-59_1) chr12:7,623,409-7,656,489 | 1.83 × 10−15 | −0.256 | n.a. | n.a. | n.a. |
| cg07839457 (NLRC5) chr16:57,023,022 | CXCL11 (3038-9_2) chr4:76,954,835-76,962,568 | 1.13 × 10−13 | −0.246 | n.a. | n.a. | n.a. |
The p-value (PpQTM, linear regression) and regression coefficient (BetapQTM) from the discovery study are reported. The chromosomal position of the CpG sites and the related protein coding genes are given, together with the associated protein and SOMAmer identifiers (SeqId). The BIOS QTL server5 was used to identify overlapping CpG methylation to gene expression associations (eQTMs). The respective p-values (peQTM, linear regression) and regression coefficients (betaeQTM) of the association of the respective CpG and the transcript are reported. All associations are located in trans, that is, the CpG and the blood circulating protein coding region were < 1 Mbp