Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 3;11:74. doi: 10.1038/s41467-019-13771-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 4 — a Initial survival rates of KTOR1 and KTOR2 when cells were exposed to ALC or vehicle in combination with the knockdown of YAP1. Summarized results are shown in this panel. Significance was evaluated using a one-way ANOVA followed by Sidak’s multiple comparison test. Complete results, including H2228, are shown in Supplement Fig. 4a). b Apoptosis assay using Caspase-Glo® in KTOR1 and KTOR2 cells exposed to ALC or vehicle in combination with the knockdown of YAP1. Significance was evaluated using a one-way ANOVA followed by Sidak’s multiple comparison test. Results for H2228 are shown in Supplementary Fig. 4b). c Cell viability assay for ALC exposure in KTOR1 and KTOR2 cells in the presence of VER, a YAP1 inhibitor. Significance was evaluated using a two-way ANOVA followed by Dunnett’s multiple comparison test. Results for H2228 are shown in Supplementary Fig. 4c). d Schematic explanation of the results in this Figure. The inhibition of YAP1 induced apoptosis and reduced initial survival when ALK-rearranged lung cancer was treated with ALC. ALC: alectinib, S.C. scramble control, VER verteporfin. Error bars indicate ± S.D. *P < 0.05.