Table 3.

Hierarchical regression analysis for predicting cognitive performance (MMSE score) at follow-up (n = 1637)

	R2Δ	R2	β	p
1. MMSE at baseline	0.085	0.085	0.292	0.000***
2. Demographic	0.112	0.197
Age			− 0.289	0.000***
Gender (1 = m, 2 = f)			0.041	0.068
Education			0.137	0.000***
3. Genetic	0.009	0.206
ApoE-ε4			− 0.092	0.000***
ApoE-ε2			0.005	0.806
4. Health	0.024	0.229
Diabetes			− 0.037	0.093
Head injury			− 0.009	0.684
Cardiovascular disease burden			0.009	0.711
Smoking			− 0.050	0.023*
Cerebrovascular disease			− 0.143	0.000***
5. Sensory/cognitive tests	0.014	0.243
Odor identification			0.056	0.016*
Vocabulary test			0.115	0.000***
6. Two-way interaction	0.003	0.246
Odor id. × ApoE-ε4			0.054	0.013*

MMSE Mini Mental State Examination

*p < 0.05; **p < 0.01; ***p < 0.001