Table III.
Population Parameter Estimates for the Dose-Response Models
| TEM | Treg | |||||
|---|---|---|---|---|---|---|
| Parameter | Units | Description | Estimate (RSE%) | IIV | Estimate (RSE%) | IIV |
| R0 | Cells μL−1 | Baseline concentration | 63.1 (8.2) | 41 (5) | 46.2 (5.7) | 33 (19) |
| kout | Day−1 | First-order disappearance rate of lymphocytes | 0.0665 (14) | – | 0.0308 (26) | – |
| Emax | Unitless | Maximum possible effect | 0.715 (9.3) | 21 (24) | 0.700 (13) | 27 (50) |
| ED50 | mg/kg/2wk | Dose at half-maximum effect | 0.353 (64) | – | 7.06 (31) | – |
| σ5 | % | Proportional residual error | 11 (14) | – | 6.1 (13) | – |
RSE relative standard error, IIV interindividual variability expressed as % coefficient of variation (% η-shrinkage), TEM effector memory T cells, Treg regulatory T cells