Table 3.
Highly interconnected CpGs in co-methylation modules associated with the MSA disease status
| Module | CpGs | Genes | Chr | Feature | Module | CpGs | Genes | Chr | Feature |
|---|---|---|---|---|---|---|---|---|---|
| Plum1a | cg20048521 | C6orf221 | 6 | TSS200 | Tanb | cg06642177 | SGK1 | 6 | Body |
| cg14428827 | 7 | IGR | cg14078059 | 12 | IGR | ||||
| cg18932707 | 6 | IGR | cg11162385 | NANP | 20 | TSS200 | |||
| cg09303171 | ITGA8 | 10 | Body | cg15238008 | DDX12 | 12 | TSS200 | ||
| cg25842050 | 5 | IGR | cg26460378 | WDR62 | 19 | TSS200 | |||
| cg16201233 | RRAGC | 1 | Body | cg16508039 | UBR5-AS1 | 8 | TSS1500 | ||
| cg06148118 | LMO2 | 11 | TSS1500 | cg02653800 | UBE2D1 | 10 | Body | ||
| cg07945047 | 7 | IGR | cg13113052 | POLI | 18 | Body | |||
| cg01495416 | 8 | IGR | cg20882291 | SDC2 | 8 | 5′UTR | |||
| cg26195291 | EPB41L2 | 6 | 5′UTR | cg14714046 | 6 | IGR | |||
| Lightcyan1 | cg06478421 | 2 | IGR | Salmon | cg01095763 | IQCA1 | 2 | Body | |
| cg16787431 | HOXB3 | 17 | Body | cg24397470 | FRMD4A | 10 | Body | ||
| cg20446143 | MS4A8B | 11 | TSS1500 | cg16905100 | 3 | IGR | |||
| cg10426234 | 12 | IGR | cg07191498 | DTNA | 18 | 5′UTR | |||
| cg08380642 | SLC9A5 | 16 | Body | cg11919558 | SERTAD2 | 2 | 5′UTR | ||
| cg18624016 | SNED1 | 2 | Body | cg05852537 | PROCR | 20 | TSS200 | ||
| cg25989511 | 5 | IGR | cg24003508 | KLF6 | 10 | Body | |||
| cg22344631 | 2 | IGR | cg18284089 | TMEM154 | 4 | TSS200 | |||
| cg02707071 | HOXA2 | 7 | TSS1500 | cg03353442 | DENND4C | 9 | 5′UTR | ||
| cg13527466 | 12 | IGR | cg04337518 | AMPD2 | 1 | TSS1500 | |||
| Turquoiseb | cg20051635 | ZAP70 | 2 | ExonBnd | Darkorangea | cg06122635 | 2 | IGR | |
| cg07600621 | 1 | IGR | cg08769544 | MEPCE | 7 | TSS1500 | |||
| cg21588562 | FTMT | 5 | TSS200 | cg07667367 | SPATA4 | 4 | TSS200 | ||
| cg16901862 | 12 | IGR | cg03309025 | 3 | IGR | ||||
| cg23523282 | 19 | IGR | cg07287188 | 17 | IGR | ||||
| cg07524919 | TNXB | 6 | Body | cg25730577 | CSF1 | 1 | TSS1500 | ||
| cg10365886 | TNXB | 6 | Body | cg00867446 | ACIN1 | 14 | 5′UTR | ||
| cg07945971 | TSPAN9 | 12 | 5′UTR | cg22506042 | P2RX1 | 17 | Body | ||
| cg00872984 | TNXB | 6 | Body | cg26538214 | KLF6 | 10 | 5′UTR | ||
| cg10923662 | TNXB | 6 | Body | cg05326918 | VPS4A | 16 | TSS1500 | ||
| Sienna3 | cg21051046 | 7 | IGR | Steelblue | cg05966983 | C1orf113 | 1 | TSS200 | |
| cg12371933 | 7 | IGR | cg12071656 | MMP9 | 20 | Body | |||
| cg19112895 | 3 | IGR | cg06213463 | MT3 | 16 | TSS200 | |||
| cg14349532 | 3 | IGR | cg00351804 | 7 | IGR | ||||
| cg18966597 | 7 | IGR | cg13609723 | NKX3-1 | 8 | Body | |||
| cg12105980 | 7 | IGR | cg07137043 | EIF4H | 7 | Body | |||
| cg06597462 | 7 | IGR | cg07008893 | CHD7 | 8 | 5′UTR | |||
| cg16929199 | 7 | IGR | cg26474620 | ST7 | 7 | Body | |||
| cg11382477 | 7 | IGR | cg19812670 | NAALADL2 | 3 | Body | |||
| cg13482308 | PAX5 | 9 | Body | cg05225581 | KBTBD6 | 13 | 1stExon | ||
| Floralwhitea | cg21734015 | FOXA3 | 19 | TSS1500 | Skyblueb | cg17398237 | MND1 | 4 | TSS200 |
| cg04599533 | LMLN | 3 | Body | cg23904393 | NCBP1 | 9 | 5′UTR | ||
| cg25471021 | MTA3 | 2 | Body | cg17430625 | MPV17L2 | 19 | Body | ||
| cg10434152 | GOLSYN | 8 | TSS200 | cg03594908 | 7 | IGR | |||
| cg25936334 | CCDC82 | 11 | 5′UTR | cg22717608 | PDHX | 11 | TSS200 | ||
| cg09170127 | ZMAT2 | 5 | Body | cg08656770 | 6 | IGR | |||
| cg13527872 | DAPK1 | 9 | Body | cg16886471 | 17 | IGR | |||
| cg13064050 | GPR37 | 7 | TSS200 | cg00116554 | SNAI2 | 8 | 1stExon | ||
| cg17819963 | PAOX | 10 | TSS1500 | cg18721249 | CAV1 | 7 | Body | ||
| cg19731597 | NCAN | 19 | TSS200 | cg00013410 | MED13 | 17 | 1stExon |
aAlso associated with the MSA mixed subtype
bAlso associated with the MSA OPCA subtype