Table 1.
Baseline characteristics for patients divided into TSP-4 tertiles
| TSP-4 tertiles | ||||||
|---|---|---|---|---|---|---|
| 1 | 2 | 3 | p value | |||
| 76.25 (65.22, 85.04) | 115.57 (104.09, 124.87) | 180.74 (150.77, 208.27) | overall | 1 vs. 3 | ||
| n | 121 | 123 | 121 | |||
| Male Gender n (%) | 82 (67.8%) | 76 | 85 (70.2%) | 0.354 | 0.677 | |
| Age | 68 ± 11 | 68 ± 10 | 71 ± 10 | 0.097 | 0.052 | |
| LDL-C (mg/dl) | 110.5 ± 39.4 | 110.1 ± 40.4 | 103.8 ± 36.1 | 0.326 | 0.377 | |
| HDL-C (mg/dl) | 52.9 ± 14.1 | 53.6 ± 14.3 | 52 ± 12.8 | 0.662 | 0.628 | |
| Lipoprotein(a) (mg/dl) | 22.0 (10.0, 75.0) | 25.5 (7.0, 87.0) | 25.0 (13.0, 78.0) | 0.781 | 0.450 | |
| BMI (kg/m²) | 27.4 ± 4.3 | 27.95 ± 4.37 | 27.1 ± 3.7 | 0.294 | 0.860 | |
| CRP (mg/dl) | 0.27 (0.14, 0.55) | 0.3 (0.14, 0.55) | 0.28 (0.16, 0.56) | 0.840 | 0.539 | |
| eGFR (ml/min/1.73 m2) | 69.3 ± 20 | 67.5 ± 18.8 | 64.9 ± 17.7 | 0.2 | 0.075 | |
| Creatinine clearance (ml/min) | 76 ± 29 | 75 ± 27 | 69 ± 24 | 0.081 | 0.087 | |
| UACR (mg/g) | 10.7 (5.3, 37.3) | 9.7 (4.7, 27.4) | 10.7 (4.7, 27.6) | 0.714 | 0.531 | |
| Triglycerides (mg/dl) | 157 ± 91 | 174.2 ± 112.4 | 164.9 ± 82.7 | 0.398 | 0.820 | |
| HbA1c (%) | 6.3 ± 0.9 | 6.3 ± 0.9 | 6.2 ± 1 | 0.997 | 0.998 | |
| Arterial hypertension n (%) | 111 (91.7%) | 114 (92.7%) | 111 (91.7%) | 0.951 | 1 | |
| Diabetes n (%) | NGT | 42 (34.7%) | 30 (24.4%) | 29 (24.2%) | 0.112 | 0.073 |
| DGT | 79 (65.3%) | 93 (75.6%) | 91 (75.8%) | |||
| Smoking habit n (%) | NEVER | 21 (17.4%) | 27 (22%) | 24 (19.8%) | 0.768 | 0.635 |
| FORMER | 53 (43.8%) | 57 (46.3%) | 57 (47.1%) | |||
| ACTIVE | 47 (38.8%) | 39 (31.7%) | 40 (33.1%) | |||
| Mediasclerosis n (%) | 29 (24%) | 30 (24.4%) | 33 (27.3%) | 0.814 | 0.556 | |
| ABI | 0.79 ± 0.17 | 0.73 ± 0.18 | 0.72 ± 0.21 | 0.031 | 0.012 | |
| TBI | 0.52 ± 0.20 | 0.45 ± 0.14 | 0.47 ± 0.19 | 0.387 | 0.347 | |
| PAD stage n (%) | I | 65 (54.2%) | 63 (51.2%) | 56 (46.3%) | 0.5 | 0.247 |
| II | 56 (46.3%) | 60 (48.8%) | 65 (53.7%) | |||
ABI is only presented for patients without mediasclerosis, TBI is only presented for patients with mediasclerosis, NGT normal glucose tolerance, DGT disturbed glucose tolerance (prediabetes and diabetes combined), LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, BMI body mass index, CRP c-reactive protein, eGFR estimated glomerular filtration rate, UACR urine albumin creatinine ratio, HbA1c haemoglobin A1c, ABI ankle–brachial index, TBI toe-brachial index
p < 0.05 significant (in bold)