Table 2.
Correlation between different genotypes of genes in MTORC1 pathway and brain metastasis
| SNP’s genes | Genotypes | Patients N = 501 (%) | Events N = 130 (%) | Univariate analysis | Multivariate analysisa | ||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | p | ||||
| mTOR:rs1883965 | GG | 394 (78.6) | 110 (38.7) | 1.000 | 1.000 | ||
| GA + AA | 107 (21.4) | 20 (23.0) | 0.731 (0.453–0.178) | 0.198 | 0.755 (0.458–1.245) | 0.271 | |
| mTOR:rs2536 | TT | 418 (83.4) | 108 (34.8) | 1.000 | 1.000 | ||
| TC + CC | 83 (16.6) | 22 (36.1) | 1.126 (0.716–1.770) | 0.607 | 1.010 (0.634–1.607) | 0.968 | |
| mLST8:rs26865 | AA | 88 (17.6) | 21 (31.3) | 1.000 | 1.000 | ||
| AG + GG | 413 (82.4) | 109 (35.9) | 2.444 (1.467–4.072) | 0.001 | 2.938 (1.664–5.189) | < 0.001 | |
| mLST8:rs3160 | TT | 139 (27.7) | 33 (31.1) | 1.000 | 1.000 | ||
| TC + CC | 362 (72.3) | 97 (36.6) | 2.050 (1.316–3.195) | 0.002 | 2.490 (1.543–4.016) | < 0.001 | |
| RPTOR:rs1062935 | TT | 164 (32.7) | 55 (50.5) | 1.000 | 1.000 | ||
| TC + CC | 337 (67.3) | 75 (28.6) | 0.678 (0.478–0.963) | 0.030 | 0.844 (0.588–1.211) | 0.357 | |
| RPTOR:rs12602885 | GG | 294 (58.7) | 70 (31.3) | 1.000 | 1.000 | ||
| GA + AA | 207 (41.3) | 60 (40.8) | 0.876 (0.615–1.247) | 0.462 | 0.853 (0.591–1.232) | 0.398 | |
| RPTOR:rs3751932 | TT | 349 (69.7) | 90 (34.7) | 1.000 | 1.000 | ||
| TC + CC | 152 (30.3) | 40 (35.7) | 0.979 (0.672–1.427) | 0.913 | 0.900 (0.606–1.335) | 0.599 | |
| RPTOR:rs3751934 | CC | 215 (42.9) | 68 (46.3) | 1.000 | 1.000 | ||
| AC + AA | 286 (57.1) | 62 (21.7) | 0.738 (0.522–1.043) | 0.085 | 0.882 (0.616–1.264) | 0.495 | |
HR hazard ratio, CI confidence interval
aMultivariate analyses in this table were adjusted for age, sex, smoking status, Karnofsky Performance Status, body mass index, tumor histology, TNM stage