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. 2019 Dec 1;33(23-24):1702–1717. doi: 10.1101/gad.332395.119

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© 2019 Wu et al.; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 3. — Cezanne UBA domain and DUB activity are essential for Rap80, Abraxas, and BRCA1 recruitment. (A) A diagram of Cezanne WT and mutants. (B) UBA and DUB activity of Cezanne are essential for Rap80, Abraxas, and BRCA1 IRIF. Cezanne KO cells were complemented with expression of GFP-tagged Cezanne WT or mutants. Nonparametric Kruskal–Wallis ANOVA was used for statistics analysis. (C) Overexpression of Cezanne DUB mutants decreases Rap80/Abraxas/BRCA1 recruitment. GFP-tagged Cezanne WT or mutants were expressed in U2OS cells. Nonparametric Kruskal–Wallis ANOVA was used for statistics analysis. (D) Western blot showing expression of GFP-tagged Cezanne WT and mutants in cells. * marks expression of indicated protein fragments.