Sections of tubes (10 mg each) formed from 5MB, 10MB, 20MB, 30MB, (14%,16%,26%,34% w/v concentrations, respectively) were subject to Protease XIV enzyme exposure for 14 days under conditions of constant orbital shaking. A 5MB group was subject to PBS (without enzyme) as a control. Dry tubes were weighed at the onset of the study and samples were removed from enzyme solutions, rinsed in DI water, dried and re-weighed at each time point. Enzyme solution was replaced at each measurement interval. While all groups exposed to enzyme lost mass throughout the study, the 5MB group was the fastest to degrade, likely due to rapid fluid transport through the large pores.