Table 1.

Eight Major Causes of Fatal Outcomes After Grouping Clozapine ADRs Reported to VigiBase

ADRs	Fatal Outcomes	Relative Lethalitya (%)	Cases
Broad pneumoniab	2077	30	6983
Sudden deaths and cardiac arrestsc	1449	90	1614
Broad agranulocytosisd	550	2	34 931
Broad myocarditise	539	12	4586
Broad constipationf	326	12	2814
Broad arrhythmiag	319	5	6927
Broad seizureh	308	5	6231
Broad syncopei	299	7	4058

Note: ADRs, adverse drug reactions.

^aRelative lethality = fatal outcomes/cases.

^bBy adding pneumonia, lower respiratory infection, and aspiration. From 7181 reports we obtained 6983 cases.

^cBy adding cardiac arrest and sudden death. From 1633 reports we obtained 1614 cases.

^eBy adding agranulocytosis, WBC decrease, neutropenia, leukopenia, neutrophil count decrease, and granulocytopenia. From 47 879 reports we obtained 34 931 cases.

^eBy adding cardiac failure, myocarditis, and cardiomyopathy. From 4839 reports we obtained 4586 cases.

^fBy adding constipation, toxic megacolon, and paralytic ileus. From 2971 reports we obtained 2814 cases.

^gBy adding tachycardia and arrhythmia. From 6987 reports we obtained 6927 cases.

^hBy adding seizures and generalized tonic-clonic seizures. From 6327 reports we obtained 6231 cases.

ⁱBy adding hypotension, syncope, and orthostatic hypotension. From 4343 reports we obtained 4058 cases.