Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jun 20;46(1):211–223. doi: 10.1093/schbul/sbz044

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Fig 5. — Analysis of Map2k7^+/− mice in behavioral assays relevant to positive symptomatology. PPI in (a) male and (b) female mice following saline or d-amphetamine (5 mg/kg). Males: effect of d-amphetamine (F_(1,131) = 14.34, P < .001) and genotype × d-amphetamine (F_(1,131) = 14.45, P < .001). Females: no significant effect of d-amphetamine or d-amphetamine × genotype. ** P < .01, *** P < .001 treatment effect (Fisher’s post hoc), ⁺⁺P < .01 genotype effect. Mean decrement in PPI (vehicle – d-amphetamine) for sex-pooled data (c) separated stimulus dB and (f) pooled dBs. * P < .05 genotype effect ((c) ANOVA, (f) Kruskal–Wallis). (d, e, and g) Ketamine effects on PPI (F_(1,95) = 11.30, P < .001) shown as % PPI for pooled-sex mice (d) effect of ketamine (F_(1,95) = 11.05, P = .002), genotype × ketamine P = .92. **P < .01 genotype effect. Mean decrement in PPI (vehicle – ketamine) for pooled-sex mice, (e) separated stimulus dB and (g) pooled dBs. (h) Basal LMA during habituation (15 min) and after saline administration (30 min). Map2k7^+/− mice showed elevated LMA relative to wild-type (WT) (F_(1,39) = 8.3, P = .01). (i) Ketamine (20 mg/kg) induced hyperactivity in both WT and Map2k7^+/− mice (F_(1,359) = 54.5, P < .001). (j) d-amphetamine (3 mg/kg) also induced hyperactivity (F_(1,353) = 1763, P < .001, pooled sex), which was significantly attenuated in male Map2k7^+/− mice relative to male WTs (**P < .01, Tukey’s post hoc).