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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: JACC Heart Fail. 2019 Aug 7;8(1):70–80. doi: 10.1016/j.jchf.2019.07.005

Table 4b.

Soluble Neprilysin Levels (ng/mL) in HFpEF NYHA Class III/IV Subset Compared to Community Based Controls without HFpEF

Adjustment HF adj mean (CI) N=114 Non-HF adj mean (CI) N=891 p-value
None 4.5 (2.8, 7.2) 8.5 (7.2, 10.0) 0.01
Smoking hx 4.5 (2.8, 7.1) 8.4 (7.1, 9.9) 0.01
Age, Gender, BMI, Smoking hx 5.5 (3.1, 9.5) 8.2 (7.0, 9.7) 0.18
Age, Gender, BMI, Smoking hx, Ace-I 5.5 (3.1, 9.9) 8.3 (7.0, 10.0) 0.20
Age, Gender, BMI, Smoking hx, Ace-I, Hyperlipidemia 5.4 (2.9, 9.9) 8.3 (7.0, 10.0) 0.19
Age, Gender, BMI, Smoking hx, HTN 5.4 (3.0, 9.8) 8.2 (6.9, 9.8) 0.18