Table 3.
Multivariable linear regression estimating associations between endothelin-1 level and cardiac structure and function (n=1,361)
| Per log increase in Endothelin-1 | |||
|---|---|---|---|
| Difference | (95% CI) | p-value | |
| Right Ventricle | 0.5 | (−1.1,2.0) | 0.57 |
| RV mass, g (Unadjusted) | |||
| RV mass, g (Limited model*) | −0.8 | (−1.9,0.4) | 0.18 |
| RV mass, g (Full Model†) | −0.8 | (−2.0, 0.3) | 0.17 |
| RVEDV, mL (Unadjusted) | 1.9 | (−8.7, 12.5) | 0.72 |
| RVEDV, mL (Limited model) | −6.0 | (−13.2, 1.2) | 0.10 |
| RVEDV, mL (Full Model) | −6.9 | (−14.0, 0.4) | 0.06 |
| RVEF, % (Unadjusted) | 0.0 | (−2.2, 2.3) | 0.99 |
| RVEF, % (Limited model) | 0.2 | (−1.9,2.3) | 0.85 |
| RVEF, % (Full Model) | −0.1 | (−2.0, 2.2) | 0.91 |
| Left Ventricle | |||
| LV mass, g (Unadjusted) | −1.8 | (−15.5,11.8) | 0.79 |
| LV mass, g (Limited model*) | −3.0 | (−12.5, 6.6) | 0.53 |
| LV mass, g (Full Model†) | −1.9 | (−11.0,7.1) | 0.67 |
| LVEDV, mL (Unadjusted) | −0.1 | (−10.8, 10.6) | 0.98 |
| LVEDV, mL (Limited model) | −8.2 | (−16.4,0.0) | 0.05 |
| LVEDV, mL (Full Model) | −8.9 | (−17.1,−0.7) | 0.03 |
| LVEF, % (Unadjusted) | 2.5 | (0.0,5.1) | 0.05 |
| LVEF, % (Limited model) | 2.8 | (0.5, 5.2) | 0.02 |
| LVEF, % (Full Model) | 2.8 | (0.5, 5.2) | 0.02 |
Abbreviations: SD=standard deviation, CI=confidence interval, RV=right ventricular,
GFR=glomerular filtration rate, EDV=end-diastolic volume, and EF=ejection fraction, LV=left ventricular, g=grams, mL=milliliters
*
Limited model: age, sex, race/ethnicity, height and weight, study site
†
Full model: Limited + education, smoking status, pack-years, hypertension, systolic blood pressure, diabetes, and cholesterol