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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Cancer Res. 2019 Oct 17;18(1):68–78. doi: 10.1158/1541-7786.MCR-19-0187

Figure 6. ELF4 regulates a network of cell cycle genes.

Figure 6.

(A) Gene ontology analysis of siELF4-downregulated genes with PANTHER reveals that ELF4 targets are preferentially associated with cell cycle pathways. (B) Cell cycle-related genes (GO: Regulation of Mitotic Cell Cycle) regulated by ELF4 form a highly connected network according to STRING. Link thickness is based on the confidence of the interaction. Nodes color-coded based on MCL clustering. (C) siELF4-upregulated genes are highly associated with neuronal processes (PANTHER), supporting the observation that ELF4 loss induces differentiation and that differentiation requires cell cycle exit. (D) Upregulated genes (GO: Neurogenesis) linked to neuronal function form a highly connected network according to STRING. Link thickness is based on the confidence of the interaction. Nodes color-coded based on MCL clustering.