Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Mol Cancer Res. 2019 Oct 17;18(1):68–78. doi: 10.1158/1541-7786.MCR-19-0187

Figure 7. miR-124 and ELF4 regulate a common set of targets in opposing directions.

Figure 7.

(A) miR-124 targets and siELF4-downregulated genes overlap significantly. Statistical significance was determined by hypergeometric distribution test. (B) MSigDb analysis of the 104 overlapping genes reveals highly enriched gene sets centered on cell cycle regulation (e.g. Fisher Dream Complex, GO Cell Cycle). (C) Protein-protein interactions between the co-targeted genes reveals a highly interconnected network. DREAM Complex targets (pink) account for a large majority of the overlapped genes (34/104). Link thickness is based on the confidence of the interaction (STRING).