Table 6.

Three-way mixed MANOVA (multivariate) and three-way mixed ANOVA (univariate) analysis of the effect of medication

		Multivariate		Univariate
		Anxiety & depression		Anxiety			Depression
		Test statistics	Sig. 2-tailed	Test statistics	Sig. 2-tailed	Effect size	Test statistics	Sig. 2-tailed	Effect size
Med.	Effect	F(2, 11)	p	F(1, 12)	p	r	F(1, 12)	p	r
B T1	Group	0.59	0.57	0.92	0.36	0.27	0.05	0.83	0.06
	Time	3.23	0.079+	5.96	0.031*	0.58	0.95	0.35	0.27
	B T1	0.94	0.42	0.19	0.68	0.12	1.65	0.22	0.35
	Group x B T1	0.87	0.45	0.54	0.48	0.21	0.11	0.74	0.10
	Time x B T1	0.18	0.84	0.33	0.58	0.16	0.04	0.84	0.06
	Group x time	4.28	0.042*	6.71	0.024*	0.60	0.44	0.52	0.19
	Group x time x B T1	0.99	0.40	0.03	0.86	0.05	1.35	0.27	0.32
A T1	Group	0.01	0.99	0.01	0.91	0.03	0.02	0.90	0.04
	Time	2.95	0.094+	6.24	0.028*	0.58	2.14	0.17	0.39
	A T1	3.17	0.082+	6.80	0.023*	0.60	1.53	0.24	0.34
	Group x A T1	0.70	0.52	1.52	0.24	0.34	0.41	0.54	0.18
	Time x A T1	0.57	0.58	1.21	0.29	0.30	0.46	0.51	0.19
	Group x time	3.03	0.090+	5.62	0.035*	0.56	0.99	0.34	0.28
	Group x time x A T1	1.41	0.29	0.15	0.71	0.11	0.86	0.37	0.26

Med.: Medication

B T1: Benzodiazepines at T1

A T1: Antidepressants at T1

*p: statistical significance p < 0.05

⁺p: trend to statistical significance: 0.05 < p < 0.10