Table 1.
The function of the substance in HCC exosomes
| Components | Functions | First author/s | Year | References |
|---|---|---|---|---|
| Rab protein, GTPase, annexin | Membrane transport and fusion | CORDONNIER M | 2017 | [34] |
| miRNA | ||||
| miR-1247-3p | Promote lung migration of liver cancer | Fang T | 2018 | [77] |
| miRNA-210 | Promotes angiogenesis | Lin XJ | 2018 | [81] |
| miR-103 | Vascular permeability and metastasis | Fang JH | 2018 | [83] |
| miR-23a-3p | Inhibits the function of T-cell | Liu J | 2019 | [99] |
| miR-122 | Improve the treatment effect | Lou G | 2015 | [117] |
| miR-335 | Novel therapeutic strategy | Wang F | 2018 | [118] |
| microRNA-25-5p | Migration、Invasion | Liu H | 2018 | [122] |
| miR-320a-PBX3 | Proliferation、metastasis | Zhang Z | 2017 | [123] |
| miR-718 | Prediction the prognosis of HCC | Sugimachi K | 2015 | [124] |
| miR-665 | Biomarker | Qu Z | 2017 | [125] |
| HSP | ||||
| HSP70, HSP60 and HSP90 | Diagnosis and treatment | CORDONNIER M | 2017 | [34] |
| lncRNA HOTAIR | The release of exosomes | YANG L | 2019 | [45] |
| RNA and DNA | Regulation cell genetics and epigenetics | ZHANG X | 2015 | [71] |
| Vps4A | Tumor suppressor | Jin-xing Wei | 2015 | [76] |
| lncRNA | ||||
| lncRNA-ATB | Novel prognosis of biomarker and therapeutic targets | Lee YR | 2019 | [110] |
| LUCAT1 and CASC9 | Biomarker | Gramantieri L | 2018 | [126] |
| circRNA | ||||
| circ-DB | Promote HCC growth and reduce DNA damage | Zhang H | 2019 | [79] |
| circPTGR1 | Clinical stage and prognosis | Wang G | 2019 | [113] |
HCC hepatocellular carcinoma, miR/miRNA micro ribonucleic acid, HSP heat shock proteins, circRNA Circular RNAs, lncRNA Long noncoding ribonucleic acid