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. 2020 Jan 3;21:9. doi: 10.1186/s13063-019-3795-4

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© The Author(s). 2020

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — SPIRIT schedule of enrolment, allocation, interventions, and assessments. MEMS, medication event management system, T1 treatment group 1, T2 treatment group 2