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. 2020 Jan 3;20:3. doi: 10.1186/s12935-019-1078-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — Overexpression of UBQLN4 could reverse tumor suppressive effect of miR-370 in HCC cells. a UBQLN4 expression under condition of miR-370 mimics, miR-370 mimics and UBQLN4 or negative control. b Cell viability of Hep-G2 and SMMC-7721 cells under treatment of miR-370 mimics, miR-370 mimics and UBQLN4 and negative control in 24 h, 48 h and 72 h. c, d Tumor formation ability and invasion ability of Hep-G2 and SMMC-7721 cells under treatment of miR-370 mimics, miR-370 mimics and UBQLN4 and negative control. e Dual luciferase assay demonstrating the effect on TOP/FOP reporter activity in Hep-G2 and SMMC-7721 cells transfected with miR-370 mimics, miR-370 mimics and UBQLN4 and negative control. Results were normalized to a Renilla transfection control. f Expression change of β-catenin, CyclinD1 and Axin2 in HCC cells under treatment of miR-370 mimics, miR-370 mimics and UBQLN4 and negative control. *p < 0.05, **p < 0.01