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. 2020 Jan 3;39:5. doi: 10.1186/s13046-019-1510-7

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — LINC00662 dramatically affected tumor growth of colon cancer in vivo (a) LINC00662 overexpression plasmids transfected HCT29 were injected with nude mouse; (b) Statistical graph of tumor weight in nude mouse carrying with LINC00662 overexpression plasmids transfected HCT29; (c) Statistical graph of tumor volume in nude mouse carrying with LINC00662 overexpression plasmids transfected HCT29; (d) LINC00662 knockdown plasmids transfected CT26 were injected with nude mouse; (e) Statistical graph of tumor weight in nude mouse carrying with LINC00662 knockdown plasmids transfected CT26; (f) Statistical graph of tumor volume in nude mouse carrying with LINC00662 knockdown plasmids transfected CT26; (g) TUNEL assay was used to detect cell apoptosis of tumor tissues carrying out LINC00662 overexpression plasmids transfected HCT29 and LINC00662 knockdown plasmids transfected CT26; (h) Immunohistochemistry assay was used to detect VEGF expression of tumor tissues carrying out LINC00662 overexpression plasmids transfected HCT29 and LINC00662 knockdown plasmids transfected CT26; (i) Immunohistochemistry assay was used to detect MMP-2 expression of tumor tissues carrying out LINC00662 overexpression plasmids transfected HCT29 and LINC00662 knockdown plasmids transfected CT26. Data are presented as the mean ± standard deviation. *P < 0.01 vs. pcDNA3.1-vector group/NC-siRNA group