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. 2020 Jan 3;20:7. doi: 10.1186/s12885-019-6502-7

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Kaplan Meyer survival curve displays the therapeutic effect of intratumoral bolus of TMZ administered at day 7 in C57BL/6 mice bearing the orthotopically syngeneic GL261 glioma. Log-rank test analysis showed significantly prolonged median survival in mice treated with 60 μg of TMZ (n = 12) compared with non-treated (n = 8). TMZ 60 μg injection vs. non-treated (*p = 0.0279). Survival was monitored for 100 days. Toxicity was present immediately after the injection in both highest doses 175 μg (2/6; 33%) and 60 μg (1/12; 8%) (pointed area)