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Grade ≥ 3 adverse events
| Grade ≥ 3 adverse events | 2019 Royal Marsden % (n = 50) (%) | 2017 study (n = 28) (%) |
2013 GRID study (n = 132) (%) |
|---|---|---|---|
| All grade ≥ 3 AEs | 23 (46) | 12 (42.9) | 81 (61.4) |
| PPE | 9 (18) | 5 (17.9) | 26 (19.7) |
| Fatigue | 7 (14) | 5 (17.9) | 3 (2.3) |
| Hypertension | 4 (8) | 2 (7.1) | 31 (23.5) |
| Hepatotoxicity | 1 (2) | 0 (0) | 1 (0.8) |
| Diarrhoea | 1 (2) | 2 (7.1) | 7 (5.3) |
| Arthralgia | 1 (2) | 0 (0) | 1 (1%) |
