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. 2019 Dec 24;111(1):266–278. doi: 10.1111/cas.14245

Figure 1.

Figure 1

A, A typical case of KRAS G12/13 mutation detected by digital PCR (dPCR). FAM‐ and HEX‐positive droplets (orange) indicate WT KRAS codon 12/13 DNA fraction; FAM‐negative, HEX‐positive (green) droplets indicate mutated KRAS codon G12/13 DNA fraction. B, Detection of mutated KRAS G12/13 by dPCR in 54 tissue DNA samples (pancreatic ductal adenocarcinoma [PDAC], 47; neuroendocrine tumor [NET], 7). KRAS mutation was detected in 45/47 PDAC samples (mutation allele frequency [MAF], 55.4%‐0.8%), whereas no KRAS mutation was detected in non‐PDAC samples