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. 2019 Dec 12;111(1):219–228. doi: 10.1111/cas.14239

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© 2019 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Chemotherapy benefits in stage II‐IV gallbladder cancer (GBC). A‐B, Kaplan‐Meier survival curves of GBC patients receiving chemotherapy or not for immunotype A and immunotype B in the training set (A) and the validation set (B). C, HR for overall survival in stage II‐IV gallbladder cancer patients receiving chemotherapy or not according to immunotype. Kaplan‐Meier survival curves of GBC patients receiving chemotherapy or not for immunotype A and immunotype B in stage II (D) and stage III‐IV (E) in the combined set. F, Subgroup analysis of chemotherapy benefits according to immunotype in stage II and stage III‐IV GBC patients. A combined set was generated by combing the training and validation set together. CI, confidence interval; HR, hazard ratio. P < 0.05 is considered statistically significant