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. Author manuscript; available in PMC: 2020 Jan 4.
Published in final edited form as: Cell Rep. 2019 Dec 24;29(13):4482–4495.e4. doi: 10.1016/j.celrep.2019.11.098

Figure 6. Validation of DE Genes in DENV-Specific DP Cells at the Protein Level.

Figure 6.

Human PBMCs isolated from Sri Lankan (SL, n = 5) and Nicaraguan (NI, n = 5) patients with acute DENV infection were stimulated with DENV MP, and the expression of various molecules was measured by CyTOF.

(A) Dot plots show the production of IFN-γ and IL-10 by CD4 T cells.

(B–G) Bar graphs show the protein expression in geometric mean values for molecules related to (B) cytotoxicity, (C) Tr1-like cells, (D) cytokines, (E) T cell activation/function, (F) migration, and (G) transcription factors in DN and DP cells.

Error bars show medians with interquartile ranges. Statistical significance was determined by two-tailed Mann-Whitney test. **p < 0.01.