Table 1.
Functional Characterization of SNHG16 in Various Cancers
| Cancer Type | Expression | Numbers of Cases | Mainly Assessed Cell Lines | Related Genes | Phenotypes Affected | Role | References |
|---|---|---|---|---|---|---|---|
| Non-small cell cancer | Up | 66 | A549 | miR-146a, MUC5AC, PCNA, MMP2, MMP9 | Proliferation, migration, invasion, tumorigenesis | Oncogenic | [32] |
| Hepatocellular carcinoma | Up | 40 | HepG2, SMMC7721 | miR-195 | Proliferation, migration, invasion, tumorigenesis | Oncogenic | [29] |
| Up | 50 | Hep-3B, Sk-hep-1 | miR-186, ROCK1 | Proliferation, migration, invasion | Oncogenic | [14] | |
| Up | 30 | HepG2 | Has-miR-17-5p, p62, mTOR, NF-κB | Proliferation, migration, invasion, cell cycle, apoptosis | Oncogenic | [26] | |
| Up | 34 | Huh7, HepG2 | miR-302a-3p, FGF19 | Proliferation | Oncogenic | [28] | |
| Up | 88 | SMMC7721 | miR-4500, STAT3, E-cadherin, N-cadherin | Proliferation, migration, invasion, EMT | Oncogenic | [27] | |
| Up | 103 | HepG2/SOR | miR-140-5p | Sorafenib resistance | Oncogenic | [25,30] | |
| Cervical cancer | Up | 78 | SiHa | miR-216-5p, ZEB1, E-cadherin, N-cadherin | Proliferation, migration, EMT | Oncogenic | [34,35] |
| Osteosarcoma | Up | 30 | SAOS2 | miR-16, ATG4B | Proliferation, migration, invasion | Oncogenic | [41] |
| Up | 96 | U2OS, SAOS2 | miR-98-5p, ZEB1, E2F5, STAT3 | Proliferation, migration, invasion, cell cycle, apoptosis | Oncogenic | [38] | |
| Up | 38 | U2OS, MG-63 | miR-1301, BCL-9 | Proliferation, migration, invasion | Oncogenic | [40] | |
| Up | 25 | U2OS, Hfob1.19, SaOS2 | miR-340, Caspase 3, caspase 7 | Viability, migration, invasion, apoptosis | Oncogenic | [15] | |
| Up | 20 | MG-63, U2OS | miR-205, ZEB1, caspase3, PARP | Proliferation | Oncogenic | [39] | |
| Papillary thyroid cancer | Up | 48 | IHH-4, TPC-1 | miR-497, BPNA, YAP1 | Proliferation, migration, invasion, apoptosis | Oncogenic | [42] |
| Glioma | Up | 40 | U251, LN229 | miR-373, PI3K, AKT, EGFR, MMP2, MMP9 | Proliferation, migration, invasion, apoptosis | Oncogenic | [48] |
| Up | 40 | LN229 | P21, cyclinD1, cyclinB1 | Proliferation, apoptosis, cell cycle | Oncogenic | [49] | |
| Up | 48 | U251, H4 | miR-4518, PRMT5, Bcl, Bax, PI3K, AKT, caspase3 | Proliferation, apoptosis | Oncogenic | [50] | |
| Colorectal cancer | Up | 56 | SW480, L0V0 | miR-200a-3p | Proliferation, migration, invasion, tumorigenesis | Oncogenic | [45] |
| Up | 281 | HCT116, SW480 | c-Myc | Viability, apoptosis, migration | Oncogenic | [13] | |
| Ovarian cancer | Up | 103 | SKOV3, H08910 | AKT, PAKT, MMP9 | Proliferation, migration, invasion | Oncogenic | [53] |
| Bladder cancer | Up | 275 | J82 | miR-17-5p, caspase3, E-cadherin, N-cadherin, TIMP3 | Viability, apoptosis, EMT, proliferation | Oncogenic | [35] |
| Up | 19 | T24 | Bcl, Bax, capase3, E-cadherin, N-cadherin, Wnt1, c-myc, P2Tkip1 | Proliferation, viability, migration, invasion, apoptosis | Oncogenic | [34] | |
| Up | 46 | T24, BIU67 | P21 | Proliferation, migration, invasion, apoptosis, cell cycle | Oncogenic | [56] | |
| Breast cancer | Up | 30 | MDA-MB-231, MCF-7 | miR-98, E2F5 | Migration | Oncogenic | [62] |
| Retinoblastoma | Up | 30 | SORB-50, Y-79 | miR-140-5p | Proliferation, colony formation | Oncogenic | [48] |
| Gastric cancer | Up | 54 | BGC-823, SGC-7901 | miR-628, NRP1 | Apoptosis | Oncogenic | [68] |
| Up | 122 | MGC-803 | JAK2, p-STAT3, miR-135a | Proliferation, migration, invasion, apoptosis | Oncogenic | [66] | |
| Pancreatic cancer | Up | 46 | ASPC-1 | miR-218-5p, HMGB1 | Migration, invasion | Oncogenic | [41] |
| Lymphoma | Up | 48 | OCL-LY7 | miR-497-5p, P1M1 | Proliferation, migration, invasion, apoptosis, cell cycle | Oncogenic | [50] |