Extended Data Figure 7. An admixture graph connecting various modern meta-populations and ancient populations or individuals.

As derived in Supplementary Information section 10, the graph features a simplified three-component model for Europeans as previously suggested³⁶ and two gene flows from a European lineage related to the ancient Siberian genome MA-1³⁵ into Native Americans and Siberians. The topology within the proto-Paleo-Eskimo clade was obtained by cycling through dozens of trees with all possible topologies of branches and admixture edges and selecting the one with the highest support and no 0-length edges within the proto-Paleo-Eskimo clade.