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Binding of DNA to PgP leads to protection from nuclease activity. (A) Schematic showing electrostatically-driven PgP binding to nucleic acids, (B) gel retardation of various PgP/DNA polyplexes prepared using various PgP/DNA ratios (N/P ratio), and (C-D) nuclease protection assay of PgP/DNA polyplexes after incubation with DNase I.
