Table 2.
Patient demographics and tumor characteristics according to smoking and alcohol status
| Total n = 130 | Smoking Status | Alcohol status | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Never | Current | Former | Unknown | p-value | Never | Ever | Unknown | p-value | ||
| Sex | 0.20 | |||||||||
| Male | 101 (77.7) | 24 (70.6) | 22 (71) | 41 (85.4) | 14 (82.4) | 0.30 | 28 (68.3) | 56 (81.2) | 17 (85) | |
| Female | 29 (22.3) | 10 (29.4) | 9 (29) | 7 (14.6) | 3 (17.6) | 13 (31.7) | 13 (18.8) | 3 (15) | ||
| Age at diagnosis (years) | ||||||||||
| < 50 | 14 (10.8) | 5 (14.7) | 6 (19.4) | 3 (6.3) | 0 (0) | 0.02 | 4 (9.8) | 10 (14.5) | 0 (0) | 0.25 |
| 50–59 | 25 (19.2) | 5 (14.7) | 11 (35.5) | 8 (16.7) | 1 (5.9) | 6 (14.6) | 16 (23.2) | 3 (15) | ||
| 60–69 | 61 (46.9) | 16 (47.1) | 13 (41.9) | 23 (47.9) | 9 (52.9) | 22 (53.7) | 30 (43.5) | 9 (45) | ||
| ≥ 70 | 30 (23.1) | 8 (23.5) | 1 (3.2) | 14 (29.2) | 7 (41.2) | 9 (22) | 13 (18.8) | 8 (40) | ||
| Primary site | ||||||||||
| Lower third | 20 (15.4) | 2 (5.9) | 6 (19.4) | 9 (18.8) | 3 (17.7) | 0.36 | 8 (19.5) | 7 (10.1) | 5 (25) | 0.18 |
| Gastro-esophageal junction | 110 (84.6) | 32 (94.1) | 25 (80.6) | 39 (81.3) | 14 (82.3) | 33 (80.5) | 62 (89.9) | 15 (75) | ||
| Siewert classification | ||||||||||
| 1 | 66 (50.8) | 18 (52.9) | 12 (38.7) | 28 (58.3) | 8 (47.1) | 0.26 | 19 (46.3) | 38 (55.1) | 9 (45) | 0.67 |
| 2 | 33 (25.4) | 8 (23.5) | 11 (35.5) | 9 (18.7) | 5 (29.4) | 11 (26.8) | 17 (24.6) | 5 (25) | ||
| 3 | 11 (8.5) | 6 (17.7) | 2 (6.4) | 2 (4.2) | 1 (5.9) | 3 (7.3) | 7 (10.1) | 1 (5) | ||
| PET responder | ||||||||||
| No | 43 (33.1) | 14 (41.2) | 12 (38.7) | 14 (29.2) | 3 (17.7) | 15 (36.6) | 25 (36.2) | 3 (15) | 0.10 | |
| Yes | 57 (43.9) | 13 (38.2) | 13 (41.9) | 23 (47.9) | 8 (47.1) | 0.64 | 21 (51.2) | 27 (39.1) | 9 (45) | |
| Unknown | 30 (23.1) | 7 (20.6) | 6 (19.4) | 11 (22.9) | 6 (35.3) | 5 (12.2) | 17 (24.6) | 8 (40) | ||
| Lymphatic vascular invasion | ||||||||||
| Yes | 90 (69.2) | 25 (73.5) | 20 (64.5) | 32 (66.7) | 13 (76.5) | 0.62 | 24 (58.5) | 52 (75.4) | 14 (70) | 0.29 |
| No | 39 (30) | 8 (23.5) | 11 (35.5) | 16 (33.3) | 4 (3.5) | 16 (39) | 17 (24.6) | 6 (30) | ||
| Unknown | 1 (0.8) | 1 (3) | 0 (0) | 0 (0) | 0 (0) | 1 (2.5) | 0 (0) | 0 (0) | ||
| Circumferential resection margin | ||||||||||
| Negative | 72 (55.4) | 20 (58.8) | 16 (51.6) | 25 (52.1) | 11 (64.7) | 0.84 | 24 (58.5) | 35 (50.7) | 13 (65) | 0.70 |
| Positive | 57 (43.8) | 14 (41.2) | 15 (48.4) | 22 (45.8) | 6 (35.3) | 17 (41.5) | 33 (47.8) | 7 (35) | ||
| Unknown | 1 (0.8) | 0 (0) | 0 (0) | 1 (2.1) | 0 (0) | 0 (0) | 1 (1.5) | 0 (0) | ||
| Differentiation | ||||||||||
| Well | 2 (1.5) | 1 (2.9) | 1 (3.23) | 0 (0) | 0 (0) | 0.39 | 0 (0) | 2 (2.9) | 0 (0) | 0.59 |
| Moderate | 50 (38.5) | 16 (47.1) | 14 (45.2) | 16 (33.3) | 4 (23.5) | 17 (41.5) | 26 (37.7) | 7 (35) | ||
| Moderate–poor | 14 (10.8) | 4 (11.8) | 2 (6.5) | 4 (8.3) | 4 (23.5) | 5 (12.2) | 5 (7.3) | 4 (20) | ||
| Poor | 64 (49.2) | 13 (38.2) | 14 (45.2) | 28 (58.3) | 9 (52.9) | 19 (46.3) | 36 (52.3) | 9 (45) | ||
| Surgical T stage | ||||||||||
| ypT1 | 11 (8.5) | 3 (8.8) | 2 (6.5) | 5 (10.4) | 1 (5.9) | 0.93 | 3 (7.3) | 7 (10.1) | 1 (5) | 0.55 |
| ypT2 | 25 (19.2) | 5 (14.7) | 7 (22.6) | 8 (16.7) | 5 (29.4) | 11 (26.8) | 9 (13) | 5 (25) | ||
| ypT3 | 89 (68.5) | 25 (73.5) | 21 (67.7) | 32 (66.7) | 11 (64.7) | 25 (61) | 50 (72.5) | 14 (70) | ||
| ypT4 | 5 (3.9) | 1 (2.9) | 1 (3.2) | 3 (6.3) | 0 (0) | 2 (4.9) | 3 (4.4) | 0 (0) | ||
| Surgical N stage | ||||||||||
| ypN 0 | 44 (33.9) | 9 (26.5) | 9 (29) | 19 (39.6) | 7 (41.2) | 0.60 | 16 (39) | 18 (26.1) | 10 (50) | 0.16 |
| ypN1 | 27 (20.8) | 6 (17.7) | 7 (22.6) | 11 (22.9) | 3 (17.7) | 9 (22) | 15 (21.7) | 3 (15) | ||
| ypN2 | 29 (2.3) | 11 (32.4) | 8 (25.8) | 9 (18.8) | 1 (5.9) | 7 (17) | 21 (30.4) | 1 (5) | ||
| ypN3 | 30 (23.1) | 8 (23.5) | 7 (22.6) | 9 (18.8) | 6 (35.3) | 9 (22) | 15 (21.7) | 5 (6) | ||
PET responder defined as a reduction in standardized uptake values of > 35%
Positive circumferential resection margin defined as tumor at or within 1 mm of the circumferential resection margin
PET-positive emission tomography scan, T stage tumor stage, N stage nodal stage