Table 3.

Esophageal adenocarcinoma survival outcomes according to smoking and alcohol status

	Dead n = 75	Alive n = 55	Unadjusted Hazard ratio (95% CI)	p-value	Adjusted Hazard ratioa (95% CI)	p-value	Adjusted Hazard ratiob (95% CI)	p-value
Overall survival
Never smoker	21	13	1.00		1.00		1.00
Current smoker	18	13	1.10 (0.58–2.07)	0.77	1.14 (0.55–2.37)	0.72	1.08 (0.51–2.26)	0.85
Former smoker	26	22	0.93 (0.53–1.67)	0.83	1.25 (0.67–2.35)	0.49	1.10 (0.58–2.10)	0.77
Unknown	10	7	1.33 (0.53–2.41)	0.75	1.19 (0.53–2.66)	0.66	0.38 (0.06–2.32)	0.29
Never alcohol	18	23	1.00		1.00		1.00
Ever alcohol	45	24	1.96 (1.13–3.38)	0.02	1.70 (0.95–3.04)	0.07	1.67 (0.93–3.01)	0.09
Unknown	12	8	1.64 (0.79–3.42)	0.18	1.73 (0.80–3.80)	0.17	4.29 (0.78–23.68)	0.09
Cancer-specific survivalc
Never smoker	19	13	1.00		1.00		1.00
Current smoker	16	13	1.03 (0.52–2.01)	0.93	1.09 (0.50–2.37)	0.83	1.02 (0.46–2.6)	0.96
Former smoker	26	22	0.96 (0.53–1.75)	0.91	1.35 (0.71–2.58)	0.35	1.19 (0.61–2.31)	0.60
Unknown	9	7	1.04 (0.47–2.29)	0.93	1.14 (0.49–2.64)	0.76	0.39 (0.06–2.47)	0.32
Never alcohol	16	23	1.00		1.00		1.00
Ever alcohol	43	24	1.99 (1.12–3.55)	0.02	1.70 (0.93–3.11)	0.09	1.66 (0.90–3.06)	0.11
Unknown	11	8	1.57 (0.72–3.39)	0.25	1.66 (0.73–3.75)	0.23	3.98 (0.71–22.37)	0.12

CI confidence intervals

^aVariables included in the adjusted analysis were age at diagnosis, gender, nodal status, circumferential resection margin, lymphovascular invasion, tumor location, and tumor differentiation

^bAdjustment was made for age at diagnosis, gender, nodal status, circumferential resection margin, lymphovascular invasion, tumor location, tumor differentiation, and smoking in the alcohol analysis and alcohol in the smoking analysis

^cThis analysis included 125 patients as 5 had died due to other causes