Table 5.
Esophageal adenocarcinoma survival outcomes according to smoking status within different biomarker categories
| Never | Ever | Smoking status | ||||||
|---|---|---|---|---|---|---|---|---|
| Dead/alive | Dead/alive | Never | Ever (Overall survival) Unadjusted hazard ratio (95% CI) |
p-value | Ever (Disease specific survival)a Unadjusted hazard ratio (95% CI) |
p-value | ||
| p53 | n = 34 | n = 79 | ||||||
| 240 + | 43 (33.1) | 6/4 | 16/9 | 1.00 | 1.22 (0.47–3.14) | 0.68 | 1.22 (0.48–3.15) | 0.68 |
| 80 to < 240 | 38 (29.2) | 8/8 | 10/11 | 1.00 | 0.68 (0.27–1.72) | 0.41 | 0.62 (0.24–1.61) | 0.33 |
| < 80 | 49 (37.7) | 7/5 | 18/15 | 1.00 | 1.18 (0.49–2.87) | 0.72 | 1.28 (0.47- 3.47) | 0.63 |
| HER-2 | n = 34 | n = 79 | ||||||
| 0 | 111 (85.4) | 18/12 | 37/28 | 1.00 | 1.07 (0.61–1.88) | 0.81 | 1.07 (0.59–1.93) | 0.83 |
| 1 | 19 (14.6) | 3/1 | 7/7 | 1.00 | 0.64 (0.16–2.48) | 0.52 | 0.64 (0.16–2.48) | 1.00 |
| GLUT 1 | n= 34 | n= 79 | ||||||
| 0 | 22 (17.1) | 5/3 | 5/6 | 1.00 | 0.75 (0.21–2.64) | 0.66 | 0.54 (0.13–2.18) | 0.39 |
| 1 | 107 (82.9) | 16/10 | 39/29 | 1.00 | 1.02 (0.57–1.83) | 0.95 | 1.07 (0.59–1.95) | 0.83 |
| CD 8 | n = 30 | n = 77 | ||||||
| 0 | 36 (30) | 5/3 | 17/6 | 1.00 | 1.32 (0.49–3.59) | 0.59 | 1.22 (0.45–3.40) | 0.69 |
| 1 | 84 (70) | 14/8 | 26/28 | 1.00 | 0.85 (0.44–1.64) | 0.63 | 0.87 (0.44–1.73) | 0.88 |
CI confidence intervals
aThis analysis included 125 patients as 5 had died due to other causes