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. 2019 Oct 9;21(1):29–43. doi: 10.1007/s10522-019-09841-2

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — mRNA transcript levels of Pten, Tsc2, Sesn1 and Dram1 genes in hippocampus of 4- and 24-month-old IL-6-deficient (IL-6KO) and wild type control (WT) mice. Level of mRNA expression was defined as log2(FC), where FC stands for fold-change difference in mRNA level between indicated groups. Bars represent mean ± SEM obtained from six animals in each group. Levels of Pten mRNA and Tsc2 mRNA were significantly higher in both 4- and 24-month-old IL-6KO mice in comparison with age-matched WT controls (**p < 0.01, and *p < 0.05, respectively). Aging was associated with significant decrease in Pten mRNA and Tsc2 mRNA levels (**p < 0.01, and *p < 0.05, respectively) in IL-6KO animals (Wilcoxon signed rank test). IL-6 deficiency was associated with statistically significant increase in Sesn1 mRNA in aged animals in comparison with respective WT group (*p < 0.05), while aging was associated with significantly decreased its mRNA transcript in WT control mice (**p < 0.01, Wilcoxon signed rank test). Deficiency of IL-6 resulted in significantly higher expression of Dram1 mRNA in 4-month-old mice (*p < 0.05), while aging diminished Dram1 mRNA level, but the effect was insignificant (Wilcoxon signed rank test). GLM analysis revealed influence of genotype on the transcription of Pten, Tsc2, and Dram1 (p < 0.0005, p <0.0005 and p <0.05, respectively), and influence of age on the transcription of Pten and Dram1 (p <0.01 and p <0.005, respectively)