Skip to main content
. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Cancer Res. 2019 Nov 5;80(1):57–68. doi: 10.1158/0008-5472.CAN-19-1676

Figure 7.

Figure 7.

A summary diagram of the results. In WT macrophages (left), treatment with PCT/Cisplatin induces the expression of WDR5 and MKL1, associating with increased H3K4 methylation, cytokine expression (i.e., MIP2) and tumor growth. Inhibition of WDR5 (OICR-9429) or MKL1 (CCG-203971) results in reduced cytokine expression. In Hpa-KO macrophages (right), the expression of SET1A, MLL1, and MKL1 are significantly lower vs. WT macrophages and their expression is not induced by PCT; H3K4 methylation is not increased by PCT/Cisplatin, nor cytokine expression.