Table 1:
Demographic and Clinical Characteristics
| All Patients (n=50) | UGT1A1 genotype group | |||
|---|---|---|---|---|
| *1/*1 (n=23) | *1/*28 (n=20) | *28/*28 (n=7) | ||
| Median Age (years, range) | 63 (37-82) | 63 (37-74) | 63 (45-82) | 65 (51-75) |
| Sex | ||||
| Female | 25 (50%) | 9 (39%) | 12 (60%) | 4 (57%) |
| Male | 25 (50%) | 14 (61%) | 8 (40%) | 3 |
| ECOG | ||||
| 0 | 20 (40%) | 10 (43%) | 9 (45%) | 1 (14%) |
| 1 | 30 (60%) | 13 (57%) | 11 (55%) | 6 (86%) |
| Race | ||||
| White | 43 (86%) | 21 (91%) | 15 (75%) | 7 (100%) |
| Black or African American | 7 (14%) | 2 (9%) | 5 (25%) | 0 |
| Diagnosis | ||||
| Pancreatic cancer | 30 (60%) | 13 (57%) | 12 (60%) | 5 (71%) |
| Biliary tract cancer | 9 (18%) | 5 (22%) | 3 (15%) | 1 (14%) |
| Gastroesophageal cancer | 6 (12%) | 2 (9%) | 3 (15%) | 1 (14%) |
| Unknown GI primary | 3 (6%) | 1 (4%) | 2 (10%) | 0 |
| Cecal neuroendocrine cancer | 1 (2%) | 1 (4%) | 0 | 0 |
| Hepatocellular carcinoma | 1 (2%) | 1 (4%) | 0 | 0 |