. Author manuscript; available in PMC: 2020 Jul 1.

Published in final edited form as: Clin Cancer Res. 2019 Sep 26;26(1):18–24. doi: 10.1158/1078-0432.CCR-19-1483

Table 2:

Dose-Limiting Toxicities and Response Rates by Genotype

	UGT1A1 genotype group			Overall (n=49)
	1/1 (n=23)	1/28 (n=19)	28/28 (n=7)
# with DLTs (%)	5 (22%)	1 (5%)	0	6 (12%)
DLT Description	Gr 3 diarrhea (3 pts) Gr 3 nausea (1 pt) Grade 3 FN (1 pt)	Grade 3 nausea (1 pt)		Gr 3 diarrhea (3 pts) Gr 3 nausea (2 pts) Grade 3 FN (1 pt)
Complete Response	1 (4%)	0	0	1 (2%)
Partial Response	6 (26%)	6 (32%)	2 (29%)	14 (29%)
Stable Disease	11 (48%)	9 (47%)	4 (57%)	24 (49%)
Disease Control	18 (78%)	15 (79%)	6 (86%)	39 (80%)
Progressive Disease	4 (17%)	2 (11%)	1 (14%)	7 (14%)
Not Evaluable	1 (4%)	2 (11%)	0	3 (6%)

Abbreviations: DLT: Dose limiting toxicity; FN: Febrile neutropenia; Gr: Grade; pt: patient