Table 2.
Reproductive history and cognitive function, women in the Bogalusa Heart Study
| logical memory | digit coding | |||||||||||||
| N§ | % | logical memory 1 | logical memory 2 | logical recognition | digit coding score | |||||||||
| B* | SE | p† | B* | SE | p† | B* | SE | p† | B* | SE | p† | |||
| nulliparous | 99 | 13.7 | −0.24 | 0.09 | 0.01 | −0.19 | 0.09 | 0.04 | −0.24 | 0.09 | 0.01 | −0.32 | 0.09 | <0.01** |
| any fertility difficulties | 128 | 17.5 | −0.10 | 0.08 | 0.21 | −0.01 | 0.08 | 0.89 | −0.06 | 0.08 | 0.48 | 0.06 | 0.08 | 0.42 |
| birth<16 years | 34 | 5.4 | −0.04 | 0.15 | 0.81 | −0.08 | 0.16 | 0.61 | 0.29 | 0.15 | 0.06 | 0.06 | 0.15 | 0.68 |
| birth<18 years | 113 | 18.0 | −0.02 | 0.09 | 0.86 | −0.08 | 0.09 | 0.37 | 0.08 | 0.09 | 0.35 | 0.00 | 0.09 | 0.98 |
| Parity 4+ | 69 | 9.5 | 0.00 | 0.11 | 0.97 | 0.08 | 0.11 | 0.44 | 0.16 | 0.11 | 0.16 | 0.08 | 0.11 | 0.47 |
| Parity 3+ | 218 | 30.1 | 0.00 | 0.07 | 0.95 | −0.04 | 0.07 | 0.55 | 0.00 | 0.07 | 0.96 | 0.09 | 0.07 | 0.18 |
| trail making test |
||||||||||||||
| trail A time | trail B time | trail B/A ratio (log) | digit span forward, total | |||||||||||
| B* | SE | p† | B* | SE | p† | B* | SE | p† | B* | SE | p† | |||
| nulliparous | 0.35 | 0.10 | <0.01** | 0.12 | 0.10 | 0.20 | 0.02 | 0.11 | 0.83 | −0.01 | 0.10 | 0.90 | ||
| any fertility difficulties | −0.07 | 0.09 | 0.45 | −0.03 | 0.09 | 0.77 | 0.14 | 0.10 | 0.17 | −0.12 | 0.09 | 0.18 | ||
| birth<16 years | −0.31 | 0.15 | 0.04 | −0.03 | 0.16 | 0.86 | −0.32 | 0.19 | 0.09 | −0.20 | 0.16 | 0.23 | ||
| birth<18 years | −0.23 | 0.08 | 0.01 | −0.04 | 0.09 | 0.64 | −0.13 | 0.11 | 0.22 | 0.11 | 0.09 | 0.28 | ||
| Parity 4+ | −0.06 | 0.12 | 0.63 | −0.07 | 0.11 | 0.52 | 0.16 | 0.13 | 0.22 | −0.01 | 0.12 | 0.96 | ||
| Parity 3+ | −0.09 | 0.08 | 0.27 | −0.05 | 0.07 | 0.47 | −0.01 | 0.08 | 0.92 | 0.02 | 0.08 | 0.78 | ||
| digit span backward, total | summary score | |||||||||||||
| B* | SE | p† | B* | SE | p† | |||||||||
| nulliparous | −0.16 | 0.09 | 0.08 | −1.50 | 0.41 | <0.01** | ||||||||
| any fertility difficulties | −0.12 | 0.08 | 0.16 | −0.41 | 0.37 | 0.27 | ||||||||
| birth<16 years | 0.06 | 0.16 | 0.72 | 0.28 | 0.69 | 0.69 | ||||||||
| birth<18 years | −0.06 | 0.09 | 0.52 | 0.17 | 0.40 | 0.67 | ||||||||
| Parity 4+ | 0.11 | 0.11 | 0.33 | 0.58 | 0.49 | 0.24 | ||||||||
| Parity 3+ | 0.02 | 0.07 | 0.80 | 0.24 | 0.32 | 0.46 | ||||||||
Adjusted for age, menopausal status, race, smoking, education, vocabulary, BMI, last known marital status, depressive symptoms.
Meets criterion (overall 0.05) for false discovery rate controlling for multiple testing
Linear models fit using maximum likelihood. Parameters combined across multiple (n=10) imputations to address missing data; average value ~t with df depending on within- and between-imputation variances (adjusted df between 597 and 717).
Outcomes are standardized to mean=0, SD=1. Summary score sums the individual standardized measures.
SE, standard error; SD, standard deviation
725 women had data on parity, 730 on fertility, and 627 on age at first pregnancy
Adjusted for age, menopausal status, race, smoking, education, vocabulary, BMI, last known marital status, depressive symptoms.
Meets criterion (overall 0.05) for false discovery rate controlling for multiple testing
Linear models fit using maximum likelihood. Parameters combined across multiple (n=10) imputations to address missing data; average value ~t with df depending on within- and between-imputation variances (adjusted df between 597 and 717).
Outcomes are standardized to mean=0, SD=1. Summary score sums the individual standardized measures.
SE, standard error; SD, standard deviation
Adjusted for age, menopausal status, race, smoking, education, vocabulary, BMI, last known marital status, depressive symptoms.
Meets criterion (overall 0.05) for false discovery rate controlling for multiple testing
Linear models fit using maximum likelihood. Parameters combined across multiple (n=10) imputations to address missing data; average value ~t with df depending on within- and between-imputation variances (adjusted df between 597 and 717).
Outcomes are standardized to mean=0, SD=1. Summary score sums the individual standardized measures.
SE, standard error; SD, standard deviation