Table 2.
Selection percentage for the optimal treatment regime (OTR) within each subgroup, and mean trial durations, for the four designs under the eight scenarios in Table 1. The accrual rate is 6 patients per month.
| Selection percentage of OTR |
Trial duration (in months) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subgroup 1 | Subgroup 2 | |||||||||||
| Scenario | TD | ITD | TDC | TDU | TD | ITD | TDC | TDU | TD | ITD | TDC | TDU |
| 1 | 88.1 | 75.4 | 89.4 | 88.6 | 85.0 | 69.4 | 89.5 | 88.8 | 23.0 | 26.0 | 360.0 | 23.0 |
| 2 | 69.2 | 58.7 | 72.4 | 72.1 | 67.1 | 56.2 | 69.0 | 70.9 | 23.1 | 26.0 | 360.0 | 23.0 |
| 3 | 73.7 | 64.0 | 74.1 | 74.7 | 73.5 | 62.2 | 72.6 | 75.9 | 23.0 | 25.9 | 360.0 | 23.0 |
| 4 | 60.9 | 46.1 | 63.4 | 47.9 | 78.4 | 66.0 | 79.7 | 78.0 | 23.1 | 26.0 | 360.0 | 23.0 |
| 5 | 72.9 | 70.0 | 78.9 | 75.8 | 85.9 | 79.0 | 87.5 | 86.9 | 23.0 | 26.0 | 360.0 | 23.0 |
| 6 | 79.8 | 74.4 | 78.0 | 72.9 | 48.0 | 59.8 | 50.8 | 45.0 | 23.0 | 26.0 | 360.0 | 23.0 |
| 7 | 82.5 | 80.9 | 83.9 | 72.4 | 95.6 | 93.1 | 96.7 | 95.3 | 23.0 | 26.0 | 360.0 | 23.0 |
| 8 | 47.2 | 35.2 | 50.9 | 38.1 | 65.6 | 58.6 | 68.0 | 54.0 | 23.0 | 26.0 | 360.0 | 23.0 |
| Average | 71.8 | 63.1 | 73.9 | 67.8 | 74.9 | 68.0 | 75.6 | 74.4 | 23.0 | 26.0 | 360.0 | 23.0 |
“TD” is the proposed two-stage trial design; “TDC” denotes the two-stage trial design based on complete (YT, YE) data; “TDU” denotes the two-stage trial design based on AR probabilities ; “ITD” denotes the independent two-stage design that conducts a separate regime-finding trial for each subgroup.