Table 3.

Regime selection percentage based on the proposed two-stage design under the eight scenarios in Table 1. The accrual rate is 6 patients per month. These values for optimal treatment regimes with $u_{c,r}>u_c^{\max }-5$ are underlined, where $u_c^{\max }={\max }_r\{u_{c,r}\}$ is the maximum utility for subgroup c, c = 1, 2.

Scenario	Schedule/dose	Subgroup 1			Subgroup 2
		1	2	3	1	2	3
1	1	0.0	0.3	38.7	0.1	0.7	33.6
	2	49.4	6.7	0.8	51.4	6.1	0.9
	3	4.0	0.1	0.0	7.1	0.1	0.0
2	1	31.7	11.8	0.3	30.0	13.1	0.2
	2	3.8	0.8	0.6	4.8	1.4	0.2
	3	9.1	37.5	4.4	8.3	37.1	4.9
3	1	1.0	17.3	0.0	3.5	16.6	0.0
	2	56.3	0.7	0.0	49.4	1.4	0.0
	3	3.1	4.2	17.4	5.2	5.0	18.9
4	1	0.1	6.3	60.9	0.9	5.8	56.7
	2	5.8	13.1	3.2	3.9	21.7	3.9
	3	2.7	7.4	0.5	1.8	5.1	0.2
5	1	1.1	8.7	3.1	1.2	5.4	3.2
	2	0.6	57.9	1.6	1.1	50.3	1.8
	3	15.0	11.1	0.9	11.0	24.6	1.4
6	1	0.9	5.2	3.2	0.8	30.6	17.4
	2	2.4	37.1	3.5	1.1	22.6	2.7
	3	42.7	5.0	0.0	22.7	2.1	0.0
7	1	1.1	45.4	4.2	1.0	35.4	2.7
	2	11.2	37.1	0.6	28.9	31.3	0.3
	3	0.4	0.0	0.0	0.4	0.0	0.0
8	1	2.4	7.2	47.2	1.9	5.3	42.3
	2	2.7	0.2	0.0	2.6	0.3	0.0
	3	21.5	11.7	7.1	13.9	10.4	23.3