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. 2020 Jan 4;17:1. doi: 10.1186/s12979-019-0172-9

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© The Author(s). 2020

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Multiple plasma EVs of immune cells dramatically declined with age. Univariable regression analysis was used to assess associations between age and the percentage of each plasma EV subset expressing the particular surface marker in HCs (n = 28). The graphs represent results with p < 0.05, while full report of all the tested markers is presented in Additional file 6: Fig. S5