Table 2.
Effect of DCM leaf extract of Gnidia glauca on locomotor activities, anxiety, and exploration-like behaviors in HFD-induced obese rats.
| Treatments (mg/kg bw) | Grid crossings | Rearing | Defecation score | Urination | Center square entries | Stretch attend postures | Latency period (sec) | Freezing (sec) | Grooming (sec) |
|---|---|---|---|---|---|---|---|---|---|
| Normal control | 37.20 ± 1.92c | 10.00 ± 1.58b | 3.60 ± 0.55b | 2.00 ± 0.71b | 9.20 ± 1.48a | 3.80 ± 0.84b | 23.20 ± 2.39b | 21.60 ± 2.70b | 15.80 ± 2.77b |
| Negative control | 21.80 ± 2.39d | 3.20 ± 0.84c | 9.00 ± 0.71a | 5.60 ± 0.55a | 3.20 ± 0.84b | 11.00 ± 1.58a | 38.80 ± 2.59a | 46.20 ± 4.15a | 29.00 ± 2.45a |
| Positive control | 39.00 ± 2.24c | 9.40 ± 1.14b | 3.60 ± 0.55b | 2.60 ± 0.55b | 8.00 ± 1.58a | 4.60 ± 1.14b | 23.40 ± 2.30b | 19.40 ± 2.41bc | 13.80 ± 1.48bc |
| HFD+200 | 41.60 ± 2.97bc | 11.20 ± 1.48ab | 3.20 ± 0.84b | 2.40 ± 0.89b | 9.20 ± 1.79a | 4.20 ± 1.30b | 20.40 ± 1.14bc | 17.80 ± 1.79bcd | 12.40 ± 2.07bc |
| HFD+250 | 46.00 ± 4.30ab | 11.00 ± 1.58ab | 3.40 ± 0.55b | 2.40 ± 0.55b | 9.40 ± 1.14a | 3.80 ± 0.84b | 18.80 ± 1.92cd | 15.60 ± 1.52cd | 11.80 ± 1.30c |
| HFD+300 | 50.40 ± 3.36a | 12.80 ± 1.30a | 2.60 ± 0.55b | 2.00 ± 1.00b | 10.20 ± 1.30a | 3.00 ± 0.71b | 15.60 ± 2.30d | 14.00 ± 1.58d | 10.20 ± 1.30c |
Results are expressed as mean ± SD. Means followed by similar lowercase letters within columns are not statistically different (p > 0.01). Analyzed by ANOVA followed by Tukey's post hoc test for multiple comparisons and separation of means among treatment groups.