Table 5.
Functions of the CircRNAs in steroid-induced ONFH.
| Evaluated circRNA(s) | Study type | Involved cells/in vivo model | Target(s) | Pathway | Functions | Dysregulation (up/down) | Species | References |
|---|---|---|---|---|---|---|---|---|
| circHIPK3 (circ_0000284) | In vitro | Osteoblasts | miR-124 | SphK1 and STAT3 | Suppress steroid-induced apoptosis and programmed necrosis of osteoblasts | Down | Human | [6] |
|
| ||||||||
| circUSP45 | In vivo and in vitro | hBMSCs and rats | miR-127-5p | PTEN/AKT | Decrease osteogenic gene expression and inhibit the proliferation of hBMSCs | Up | Human and rat | [54] |
|
| ||||||||
| cPWWP2A | In vitro | Osteoblasts | miR-579 | SIRT1 and PDK1 | Suppress steroid-induced apoptosis and programmed necrosis of osteoblasts | Down | Human | [55] |
Note. CircRNAs, circular RNAs; ONFH, osteonecrosis of the femoral head; BMSCs, bone marrow mesenchymal stem cells.