Table 2.
The association between the ADRB3 genotype and the risk of NAFLD in the overall study population.
| Bivariable | Multivariable | |||
|---|---|---|---|---|
| OR [95% CI] | p value∗ | OR [95% CI] | p value∗ | |
| ADRB3 rs4994 genotype | ||||
| T/T | 1 | — | 1 | — |
| T/C | 1.28 [0.84-1.96] | 0.26 | 1.53 [0.91-2.57] | 0.11 |
| C/C | 1.95 [0.77-4.93] | 0.16 | 2.31 [0.67-8.01] | 0.19 |
| Age | 0.98 [0.96-0.99] | <0.01 | 0.97 [0.95-0.99] | <0.01 |
| Gender | ||||
| Male | 1 | — | ||
| Female | 0.57 [0.37-0.87] | <0.01 | ||
| BMI | 1.55 [1.41-1.71] | <0.01 | 1.42 [1.27-1.58] | <0.01 |
| HOMA-IR | 2.22 [1.75-2.81] | <0.01 | 1.73 [1.35-2.23] | <0.01 |
| Diabetes | ||||
| Absent | 1 | — | ||
| Present | 2.54 [1.52-4.25] | <0.01 | ||
| Dyslipidemia | ||||
| Absent | 1 | — | 1 | — |
| Present | 4.21 [2.58-6.87] | <0.01 | 3.69 [2.06-6.61] | <0.01 |
| Alcohol intake | ||||
| Nondrinker | 1 | — | ||
| Drinker | 0.97 [0.65-1.45] | 0.88 | ||
| Smoking status | ||||
| Never smoker | 1 | — | ||
| Ever smoker | 1.58 [1.05-2.38] | 0.03 | ||
ADRB3: beta-3-adrenergic receptor; NAFLD: nonalcoholic fatty liver disease; BMI: body mass index; OR: odds ratio; CI: confidence interval. ∗Analyzed using a logistic regression analysis.