Table 2.
Innate lymphoid cells in the gut.
| Types | Surface marker | Stimulus | Regulatory transcription factor | Signature released cytokines | Functions in the gut barrier | |
|---|---|---|---|---|---|---|
| Mouse | Human | |||||
| ILC1 | CD160 | CD103 | IL-12, IL-15 | T-bet | IFN-γ, TNF-α, GM-CSF, granzyme, perforin | Defense against virus, pathogens |
| NKp46 | CD160 | |||||
| NK1.1 | CD56 | |||||
| NKp46 | ||||||
| NKp44 | ||||||
|
| ||||||
| ILC2 | IL17RB | IL17RB | IL-25, IL-33, TSLP | GATA3 | IL-4, IL-5, IL-13, IL-9, amphiregulin | Helminth expulsion |
| IL-33R | IL-33R | |||||
| CD25 | CD25 | |||||
| CD127 | CD127 | |||||
| CRTH2 | ||||||
|
| ||||||
| ILC3 | NKp46 | NKp44 | IL-1β, IL-23, NCR ligand | RORγT | IL-17, IL-22, GM-CSF, TNF-α | Defense against bacteria, fungi |