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. 2019 Dec 24;2019:7252013. doi: 10.1155/2019/7252013

Figure 1.

Figure 1

Biogenesis process of miR-221/222. The gene of miR-221/222 is transcribed into primary miR-221/222 (pri-miR-221/222) by RNA polymerase II in nucleus and then processed to a stem-loop precursor miR-221/222 (pre-miR-221/222) by the nuclear RNase Drosha in the nucleus. Pre-miR-221/222 is transported from the nucleus to the cytoplasm by the exportin-5 transporter, in which the endoribonuclease Dicer cleaves it into a double-stranded miRNA, one of which binds to the RNA-induced silencing complex (RISC).